Vast ammount of data manipulation between Excel and VB.NET

Hello,

I would kindly ask for a direction for the following dilema:

I have huge XLSX sheet where I perform approximately 2000 calculations and about 100 graphs. It took me more then 1 year to build it up..
Now I need a standalone application to look more professional then bare Excel. Of course for now Excel will still work behind VB.NET app.

The tasks to be done are:
- reading TAG's from Excel (Process TAG / MIN value / MID value / MAX value )
- selecting tags where values can be changed
- changed values will be applied back to Excel where they will be used to apply new conditional formatting (cell coloring according to formating values)
- generating printout sheets (already made in Excel, so I need only to select sheet and print area)

I started with listbox, moved ahead to datagridview and now I read more and more about using databases... It looks preety scarry.. ;(

What would you recommend me to go for??

Any tip will be highly appreciated! :wave:

Thank you!